CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.410.40
Functional Family 5-(hydroxymethyl)furfural oxidase

Enzyme Information

1.1.3.47
5-(hydroxymethyl)furfural oxidase.
based on mapping to UniProt E4QP00
5-(hydroxymethyl)furfural + 3 O(2) + 2 H(2)O = furan-2,5-dicarboxylate + 3 H(2)O(2).
-!- The enzyme, characterized from the bacterium Methylovorus sp. strain MP688, is involved in the degradation and detoxification of 5-(hydroxymethyl)furfural. -!- The enzyme acts only on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation. -!- The enzyme has a broad substrate range that overlaps with EC 1.1.3.7.
1.8.3.-
With oxygen as acceptor.
based on mapping to UniProt E4QP00

UniProtKB Entries (1)

E4QP00
HMFO_METS6
Methylovorus sp. MP688
5-(hydroxymethyl)furfural oxidase

PDB Structure

PDB 4UDQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Dijkman, W.P., Binda, C., Fraaije, M.W., Mattevi, A.
Acs Catalysis