CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Putative Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75460
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt O75460

UniProtKB Entries (1)

O75460
ERN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 4U6R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.
Harrington, P.E., Biswas, K., Malwitz, D., Tasker, A.S., Mohr, C., Andrews, K.L., Dellamaggiore, K., Kendall, R., Beckmann, H., Jaeckel, P., Materna-Reichelt, S., Allen, J.R., Lipford, J.R.
Acs Med.Chem.Lett.