CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family Metallo-beta-lactamase NDM-1

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt C7C422
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

C7C422
BLAN1_KLEPN
Klebsiella pneumoniae
Metallo-beta-lactamase type 2

PDB Structure

PDB 4U4L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the metallo-beta-lactamase NDM-1 in complex with a bisthiazolidine inhibitor
Kosmopoulou, M., Hinchliffe, P., Spencer, J.
To Be Published