CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family TRAF2 and NCK-interacting protein kinase isoform 4

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O95819
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O95819
M4K4_HUMAN
Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 4

PDB Structure

PDB 4U42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
Wu, P., Chen, H., Coons, M., Crawford, T.D., Kirkpatrick, D.S., Murray, L., Ndubaku, C.O., Nonomiya, J., Pham, V., Schmidt, S., Smysczek, T., Vitorino, P., Ye, W., Harris, S.F.
to be published