CATH Classification

Domain Context

CATH Clusters

Superfamily 2'-5'-oligoadenylate synthetase 1, domain 2
Functional Family 2'-5'-oligoadenylate synthetase 1

Enzyme Information

2.7.7.84
2'-5' oligoadenylate synthase.
based on mapping to UniProt Q29599
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.
-!- The enzyme is activated by binding to double-stranded RNA. -!- The resulting product binds to and activates RNase L, which subsequently degrades the RNA. -!- Oligoadenylates of chain lengths 2, 4 and 5 are also produced. -!- The dimer does not have any known biological activity.

UniProtKB Entries (1)

Q29599
OAS1_PIG
Sus scrofa
2'-5'-oligoadenylate synthase 1

PDB Structure

PDB 4RWN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Lohofener, J., Steinke, N., Kay-Fedorov, P., Baruch, P., Nikulin, A., Tishchenko, S., Manstein, D.J., Fedorov, R.
Structure