CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 4RUT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
13-methylarachidonic Acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.
Kudalkar, S.N., Nikas, S.P., Kingsley, P.J., Xu, S., Galligan, J.J., Rouzer, C.A., Banerjee, S., Ji, L., Eno, M.R., Makriyannis, A., Marnett, L.J.
J.Biol.Chem.