CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family receptor-type tyrosine-protein kinase FLT3

Enzyme Information
Receptor protein-tyrosine kinase.
based on mapping to UniProt P36888
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Receptor-type tyrosine-protein kinase FLT3

PDB Structure

External Links
Primary Citation
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Smith, C.C., Zhang, C., Lin, K.C., Lasater, E.A., Zhang, Y., Massi, E., Damon, L.E., Pendleton, M., Bashir, A., Sebra, R., Perl, A., Kasarskis, A., Shellooe, R., Tsang, G., Carias, H., Powell, B., Burton, E.A., Matusow, B., Zhang, J., Spevak, W., Ibrahim, P.N., Le, M.H., Hsu, H.H., Habets, G., West, B.L., Bollag, G., Shah, N.P.
Cancer Discov