CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt Q9NYY3
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q9NYY3
PLK2_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK2

PDB Structure

PDB 4RS6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the polo-box domain of polo-like kinase 2
Shan, H.M., Wang, T., Quan, J.M.
Biochem.Biophys.Res.Commun.