CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family 3-phosphoinositide-dependent protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O15530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O15530
PDPK1_HUMAN
Homo sapiens
3-phosphoinositide-dependent protein kinase 1

PDB Structure

PDB 4RQK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier, T.J., Sadowsky, J.D., Thomsen, N.D., Chen, S.C., Doak, A.K., Arkin, M.R., Wells, J.A.
Proc.Natl.Acad.Sci.USA