CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, Y-family, little finger domain
Functional Family DNA polymerase eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253
POLH_HUMAN
Homo sapiens
DNA polymerase eta

PDB Structure

PDB 4RNO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
Patra, A., Zhang, Q., Lei, L., Su, Y., Egli, M., Guengerich, F.P.
J.Biol.Chem.