CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Casein kinase II subunit alpha

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P68400
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400
CSK21_HUMAN
Homo sapiens
Casein kinase II subunit alpha

PDB Structure

PDB 4RLL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.
Guerra, B., Rasmussen, T.D., Schnitzler, A., Jensen, H.H., Boldyreff, B.S., Miyata, Y., Marcussen, N., Niefind, K., Issinger, O.G.
Cancer Lett