CATH Domain 4rl0A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family	Metallo-beta-lactamase NDM-1

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt C7C422

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

C7C422

BLAN1_KLEPN

Klebsiella pneumoniae

Metallo-beta-lactamase type 2

PDB Structure

PDB	4RL0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. Feng, H., Ding, J., Zhu, D., Liu, X., Xu, X., Zhang, Y., Zang, S., Wang, D.C., Liu, W. J.Am.Chem.Soc.