CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Functional Family | Alpha-ketoglutarate-dependent dioxygenase AlkB |
Enzyme Information
| 1.14.11.33 |
DNA oxidative demethylase.
based on mapping to UniProt P05050
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
-!- Activity is slightly stimulated by ascorbate. -!- Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine. -!- It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
|
UniProtKB Entries (1)
| P05050 |
ALKB_ECOLI
Escherichia coli K-12
Alpha-ketoglutarate-dependent dioxygenase AlkB
|
PDB Structure
| PDB | 4RFR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.
J.Biol.Chem.
|