CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1740.10
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt P9WNS1
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P9WNS1
DXR_MYCTU
Mycobacterium tuberculosis H37Rv
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 4RCV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces.
Kholodar, S.A., Allen, C.L., Gulick, A.M., Murkin, A.S.
J.Am.Chem.Soc.