CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.230.10
Functional Family DNA topoisomerase 2

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P11388
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P11388
TOP2A_HUMAN
Homo sapiens
DNA topoisomerase 2-alpha

PDB Structure

PDB 4R1F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the N-Terminal Gyrase B Fragment in Complex with ADPPi Reveals Rigid-Body Motion Induced by ATP Hydrolysis
Stanger, F.V., Dehio, C., Schirmer, T.
Plos One