CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Extended spectrum beta-lactamase GES-11

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P16897
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.
3.5.2.6
Beta-lactamase.
based on mapping to UniProt P62593
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (2)

P62593
BLAT_ECOLX
Escherichia coli
Beta-lactamase TEM
P16897
BLP4_PSEAI
Pseudomonas aeruginosa
Beta-lactamase PSE-4

PDB Structure

PDB 4QY6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
Park, J., Gobeil, S., Pelletier, J.N., Berghuis, A.M.
To be Published