CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family cGMP-dependent protein kinase

Enzyme Information

2.7.11.12
cGMP-dependent protein kinase.
based on mapping to UniProt Q13976
ATP + a protein = ADP + a phosphoprotein.
-!- cGMP is required to activate this enzyme. -!- The enzyme occurs as a dimer in higher eukaryotes. -!- The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. -!- This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates. -!- The enzyme also has two allosteric cGMP-binding sites (sites A and B). -!- Binding of cGMP causes a conformational change that is associated with activation of the kinase. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13976
KGP1_HUMAN
Homo sapiens
CGMP-dependent protein kinase 1

PDB Structure

PDB 4QXK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Huang, G.Y., Gerlits, O.O., Blakeley, M.P., Sankaran, B., Kovalevsky, A.Y., Kim, C.
Biochemistry