CATH Domain 4qu2B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.10	Jelly Rolls

Domain Context

CATH Clusters

Superfamily	Jelly Rolls
Functional Family

Enzyme Information

1.14.11.63

Peptidyl-lysine (3S)-dioxygenase.

based on mapping to UniProt P0C872

A [protein]-L-lysine + 2-oxoglutarate + O(2) = a [protein]-(3S)-hydroxy- L-lysine + succinate + CO(2).

-!- Requires iron(II). -!- The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. -!- The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.

3.4.-.-

Acting on peptide bonds (peptidases).

based on mapping to UniProt P0C872

UniProtKB Entries (1)

P0C872

JMJD7_MOUSE

Mus musculus

Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7

PDB Structure

PDB	4QU2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structure of JMJD7 with alpha-KG Liu, H.L., Wang, C., Dege, C., Ning, F.K., Weisz, J., Hansen, K., Chen, Z.Z., Pan, C.H., Nho, C.W., Nix, J., Marrack, P., Kappler, J., Hagmen, J., Zhang, G.Y. To be Published