CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family |
Enzyme Information
| 3.3.2.9 |
Microsomal epoxide hydrolase.
based on mapping to UniProt Q6U6J0
(1) Cis-stilbene oxide + H(2)O = (1R,2R)-1,2-diphenylethane-1,2-diol. (2) 1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3- yl)methyl)methanamine + H(2)O = 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3- diol.
-!- This is a key hepatic enzyme that catalyzes the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. -!- The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo(4.1.0)hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. -!- The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. -!- Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9, EC 3.3.2.10 and EC 3.3.2.11.
|
UniProtKB Entries (1)
| Q6U6J0 |
HYEP_BOMMO
Bombyx mori
Juvenile hormone epoxide hydrolase
|
PDB Structure
| PDB | 4QLA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori
Proteins
|