CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 4QJC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
Cody, V., Pace, J., Namjoshi, O.A., Gangjee, A.
Acta Crystallogr F Struct Biol Commun