CATH Classification

Domain Context

CATH Clusters

Superfamily Scavenger mRNA decapping enzyme, N-terminal domain
Functional Family m7GpppX diphosphatase

Enzyme Information

3.6.1.59
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
based on mapping to UniProt Q96C86
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].
-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96C86
DCPS_HUMAN
Homo sapiens
M7GpppX diphosphatase

PDB Structure

PDB 4QDV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dcps in complex with covalent ligands targeting Tyrosines
Liu, S.
To be Published