CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Diacylglycerol acyltransferase/mycolyltransferase Ag85C

Enzyme Information

2.3.1.122
Trehalose O-mycolyltransferase.
based on mapping to UniProt P9WQN9
2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate.
-!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.
2.3.1.20
Diacylglycerol O-acyltransferase.
based on mapping to UniProt P9WQN9
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
-!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

UniProtKB Entries (1)

P9WQN9
A85C_MYCTU
Mycobacterium tuberculosis H37Rv
Diacylglycerol acyltransferase/mycolyltransferase Ag85C

PDB Structure

PDB 4QDU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
Favrot, L., Lajiness, D.H., Ronning, D.R.
J.Biol.Chem.