CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.730
Functional Family DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P09884
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P09884
DPOLA_HUMAN
Homo sapiens
DNA polymerase alpha catalytic subunit

PDB Structure

PDB 4QCL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Activity and fidelity of human DNA polymerase alpha depend on primer structure
Baranovskiy, A.G., Duong, V., Babayeva, N.D., Zhang, Y., Pavlov, Y., Anderson, K., Tahirov, T.H.
J.Biol.Chem.