CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Glycylpeptide N-tetradecanoyltransferase

Enzyme Information

2.3.1.97
Glycylpeptide N-tetradecanoyltransferase.
based on mapping to UniProt Q9UVX3
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].
-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.

UniProtKB Entries (1)

Q9UVX3
NMT_ASPFU
Aspergillus fumigatus Af293
Glycylpeptide N-tetradecanoyltransferase

PDB Structure

PDB 4QBJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of N-myristoyltransferase from Aspergillus fumigatus
Shimada, T., Suzuki, M., Katakura, S.
Acta Crystallogr.,Sect.D