CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase family B, C-terminal domain
Functional Family DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P09884
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P09884
DPOLA_HUMAN
Homo sapiens
DNA polymerase alpha catalytic subunit

PDB Structure

PDB 4Q5V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for inhibition of DNA replication by aphidicolin.
Baranovskiy, A.G., Babayeva, N.D., Suwa, Y., Gu, J., Pavlov, Y.I., Tahirov, T.H.
Nucleic Acids Res.