CATH Domain 4q15A01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family	Bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15

Proline--tRNA ligase.

based on mapping to UniProt Q8I5R7

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

UniProtKB Entries (1)

SYP_PLAF7

Plasmodium falciparum 3D7

Proline--tRNA ligase

PDB Structure

PDB	4Q15
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Nakazawa Hewitt, S., Dranow, D.M., Horst, B.G., Abendroth, J.A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K.L., Hulverson, M.A., Dumais, M., Edwards, T.E., Lorimer, D.D., Fairlamb, A.H., Gray, D.W., Read, K.D., Lehane, A.M., Kirk, K., Myler, P.J., Wernimont, A., Walpole, C.S., Stacy, R., Barrett, L.K., Gilbert, I.H., Van Voorhis, W.C. Acs Infect Dis.