CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family Bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15
Proline--tRNA ligase.
based on mapping to UniProt Q8I5R7
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

UniProtKB Entries (1)

Q8I5R7
SYP_PLAF7
Plasmodium falciparum 3D7
Proline--tRNA ligase

PDB Structure

PDB 4Q15
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Nakazawa Hewitt, S., Dranow, D.M., Horst, B.G., Abendroth, J.A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K.L., Hulverson, M.A., Dumais, M., Edwards, T.E., Lorimer, D.D., Fairlamb, A.H., Gray, D.W., Read, K.D., Lehane, A.M., Kirk, K., Myler, P.J., Wernimont, A., Walpole, C.S., Stacy, R., Barrett, L.K., Gilbert, I.H., Van Voorhis, W.C.
Acs Infect Dis.