CATH Domain 4pywA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.497	Antithrombin; Chain I, domain 2
	3.30.497.10	Antithrombin, subunit I, domain 2

Domain Context

CATH Clusters

Superfamily	Antithrombin, subunit I, domain 2
Functional Family	Serine protease inhibitor

Enzyme Information

UniProtKB Entries (1)

A1AT_HUMAN

Homo sapiens

Alpha-1-antitrypsin

PDB Structure

PDB	4PYW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An integrative approach combining ion mobility mass spectrometry, X-ray crystallography and NMR spectroscopy to study the conformational dynamics of alpha 1 -antitrypsin upon ligand binding. Nyon, M.P., Prentice, T., Day, J., Kirkpatrick, J., Sivalingam, G.N., Levy, G., Haq, I., Irving, J.A., Lomas, D.A., Christodoulou, J., Gooptu, B., Thalassinos, K. Protein Sci.