CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Methylglyoxal reductase (NADPH-dependent) |
Enzyme Information
| 1.1.1.265 |
3-methylbutanal reductase.
based on mapping to UniProt Q12068
3-methylbutanol + NAD(P)(+) = 3-methylbutanal + NAD(P)H.
-!- The enzyme purified from Saccharomyces cerevisiae catalyzes the reduction of a number of straight-chain and branched aldehydes, as well as some aromatic aldehydes.
|
| 1.1.1.283 |
Methylglyoxal reductase (NADPH).
based on mapping to UniProt Q12068
(S)-lactaldehyde + NADP(+) = 2-oxopropanal + NADPH.
-!- The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products. -!- Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one. -!- The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
|
UniProtKB Entries (1)
| Q12068 |
GRE2_YEAST
Saccharomyces cerevisiae S288C
NADPH-dependent methylglyoxal reductase GRE2
|
PDB Structure
| PDB | 4PVD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2
Biochim.Biophys.Acta
|