CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family B-Raf proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P15056
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056
BRAF_HUMAN
Homo sapiens
Serine/threonine-protein kinase B-raf

PDB Structure

PDB 4PP7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
Wenglowsky, S., Ren, L., Grina, J., Hansen, J.D., Laird, E.R., Moreno, D., Dinkel, V., Gloor, S.L., Hastings, G., Rana, S., Rasor, K., Sturgis, H.L., Voegtli, W.C., Vigers, G., Willis, B., Mathieu, S., Rudolph, J.
Bioorg.Med.Chem.Lett.