CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04629
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04629
NTRK1_HUMAN
Homo sapiens
High affinity nerve growth factor receptor

PDB Structure

PDB 4PMM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
Stachel, S.J., Sanders, J.M., Henze, D.A., Rudd, M.T., Su, H.P., Li, Y., Nanda, K.K., Egbertson, M.S., Manley, P.J., Jones, K.L., Brnardic, E.J., Green, A., Grobler, J.A., Hanney, B., Leitl, M., Lai, M.T., Munshi, V., Murphy, D., Rickert, K., Riley, D., Krasowska-Zoladek, A., Daley, C., Zuck, P., Kane, S.A., Bilodeau, M.T.
J.Med.Chem.