CATH Classification

Domain Context

CATH Clusters

Superfamily Toxin ADP-ribosyltransferase; Chain A, domain 1
Functional Family

Enzyme Information

3.4.24.83
Anthrax lethal factor endopeptidase.
based on mapping to UniProt P15917
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917
LEF_BACAN
Bacillus anthracis
Lethal factor

PDB Structure

PDB 4PKT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Maize, K.M., Kurbanov, E.K., De La Mora-Rey, T., Geders, T.W., Hwang, D.J., Walters, M.A., Johnson, R.L., Amin, E.A., Finzel, B.C.
Acta Crystallogr.,Sect.D