CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.480
Functional Family

Enzyme Information

1.13.11.52
Indoleamine 2,3-dioxygenase.
based on mapping to UniProt P14902
(1) D-tryptophan + O(2) = N-formyl-D-kynurenine. (2) L-tryptophan + O(2) = N-formyl-L-kynurenine.
-!- Requires ascorbic acid and methylene blue for activity. -!- Has broader substrate specificity than EC 1.13.11.11. -!- Is induced in response to pathological conditions and host-defense mechanisms. -!- While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. -!- Superoxide radicals can replace O(2) as oxygen donor.

UniProtKB Entries (1)

P14902
I23O1_HUMAN
Homo sapiens
Indoleamine 2,3-dioxygenase 1

PDB Structure

PDB 4PK6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.
Tojo, S., Kohno, T., Tanaka, T., Kamioka, S., Ota, Y., Ishii, T., Kamimoto, K., Asano, S., Isobe, Y.
Acs Med.Chem.Lett.