CATH Domain 4pieA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.395	Adenoviral Proteinase; Chain
	3.40.395.10	Adenoviral Proteinase; Chain A

Domain Context

CATH Clusters

Superfamily	Adenoviral Proteinase; Chain A
Functional Family	Protease

Enzyme Information

3.4.22.39

Adenain.

based on mapping to UniProt P03252

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid).

-!- A cysteine endopeptidase from adenoviruses. -!- Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site. -!- Belongs to peptidase family C5.

UniProtKB Entries (1)

P03252

PRO_ADE02

Human adenovirus 2

Protease

PDB Structure

PDB	4PIE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and structure-based optimization of adenain inhibitors. Mac Sweeney, A., Grosche, P., Ellis, D., Combrink, K., Erbel, P., Hughes, N., Sirockin, F., Melkko, S., Bernardi, A., Ramage, P., Jarousse, N., Altmann, E. Acs Med.Chem.Lett.