CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cruzipain

Enzyme Information

3.4.22.51
Cruzipain.
based on mapping to UniProt P25779
Broad endopeptidase specificity similar to that of cathepsin L.
-!- Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25779
CYSP_TRYCR
Trypanosoma cruzi
Cruzipain

PDB Structure

PDB 4PI3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
Jones, B.D., Tochowicz, A., Tang, Y., Cameron, M.D., McCall, L.I., Hirata, K., Siqueira-Neto, J.L., Reed, S.L., McKerrow, J.H., Roush, W.R.
Acs Med.Chem.Lett.