CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family

Enzyme Information

2.7.1.137
Phosphatidylinositol 3-kinase.
based on mapping to UniProt Q8NEB9
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

Q8NEB9
PK3C3_HUMAN
Homo sapiens
Phosphatidylinositol 3-kinase catalytic subunit type 3

PDB Structure

PDB 4PH4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle, W.E., Nyfeler, B., Nagel, J., Elling, R.A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., Cantwell, J., Luu, C., Cornella-Taracido, I., Harrington, E., Fekkes, P., Lei, H., Fang, Q., Digan, M.E., Burdick, D., Powers, A.F., Helliwell, S.B., D'Aquin, S., Bastien, J., Wang, H., Wiederschain, D., Kuerth, J., Bergman, P., Schwalb, D., Thomas, J., Ugwonali, S., Harbinski, F., Tallarico, J., Wilson, C.J., Myer, V.E., Porter, J.A., Bussiere, D.E., Finan, P.M., Labow, M.A., Mao, X., Hamann, L.G., Manning, B.D., Valdez, R.A., Nicholson, T., Schirle, M., Knapp, M.S., Keaney, E.P., Murphy, L.O.
Nat.Cell Biol.