CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P23526
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P23526
SAHH_HUMAN
Homo sapiens
Adenosylhomocysteinase

PDB Structure

PDB 4PFJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
Wang, Y., Kavran, J.M., Chen, Z., Karukurichi, K.R., Leahy, D.J., Cole, P.A.
J.Biol.Chem.