CATH Domain 4pf9B04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.830	Cytochrome Bc1 Complex; Chain A, domain 1
	3.30.830.10	Metalloenzyme, LuxS/M16 peptidase-like

Domain Context

CATH Clusters

Superfamily	Metalloenzyme, LuxS/M16 peptidase-like
Functional Family	Insulin-degrading enzyme

Enzyme Information

3.4.24.56

Insulysin.

based on mapping to UniProt P14735

Degradation of insulin, glucagon and other polypeptides. No action on proteins.

-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735

IDE_HUMAN

Homo sapiens

Insulin-degrading enzyme

PDB Structure

PDB	4PF9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. Durham, T.B., Toth, J.L., Klimkowski, V.J., Cao, J.X., Siesky, A.M., Alexander-Chacko, J., Wu, G.Y., Dixon, J.T., McGee, J.E., Wang, Y., Guo, S.Y., Cavitt, R.N., Schindler, J., Thibodeaux, S.J., Calvert, N.A., Coghlan, M.J., Sindelar, D.K., Christe, M., Kiselyov, V.V., Michael, M.D., Sloop, K.W. J.Biol.Chem.