CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase RAD53

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P22216
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P22216
RAD53_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase RAD53

PDB Structure

PDB 4PDS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.
Wybenga-Groot, L.E., Ho, C.S., Sweeney, F.D., Ceccarelli, D.F., McGlade, C.J., Durocher, D., Sicheri, F.
Cell Signal.