CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13153
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153
PAK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PAK 1

PDB Structure

PDB 4P90
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity.
McCoull, W., Hennessy, E.J., Blades, K., Box, M.R., Chuaqui, C., Dowling, J.E., Davies, C.D., Ferguson, A.D., Goldberg, F.W., Howe, N.J., Kemmitt, P.D., Lamont, G.M., Madden, K., McWhirter, C., Varnes, J.G., Ward, R.A., Williams, J.D., Yang, B.
MEDCHEMCOMM