CATH Classification

Domain Context

CATH Clusters

Superfamily 1.25.50.20
Functional Family Leucyl-cystinyl aminopeptidase

Enzyme Information

3.4.11.3
Cystinyl aminopeptidase.
based on mapping to UniProt Q9UIQ6
Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half- cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
-!- Belongs to peptidase family M1.

UniProtKB Entries (1)

Q9UIQ6
LCAP_HUMAN
Homo sapiens
Leucyl-cystinyl aminopeptidase

PDB Structure

PDB 4P8Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Hermans, S.J., Ascher, D.B., Hancock, N.C., Holien, J.K., Michell, B.J., Yeen Chai, S., Morton, C.J., Parker, M.W.
Protein Sci.