CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.27
Cathepsin S.
based on mapping to UniProt P25774
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25774
CATS_HUMAN
Homo sapiens
Cathepsin S

PDB Structure

PDB 4P6E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Jadhav, P.K., Schiffler, M.A., Gavardinas, K., Kim, E.J., Matthews, D.P., Staszak, M.A., Coffey, D.S., Shaw, B.W., Cassidy, K.C., Brier, R.A., Zhang, Y., Christie, R.M., Matter, W.F., Qing, K., Durbin, J.D., Wang, Y., Deng, G.G.
Acs Med.Chem.Lett.