CATH Domain 4p59A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.80	Alpha-Beta Horseshoe
	3.80.20	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
	3.80.20.20	Receptor L-domain

Domain Context

CATH Clusters

Superfamily	Receptor L-domain
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P21860

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21860

ERBB3_HUMAN

Homo sapiens

Receptor tyrosine-protein kinase erbB-3

PDB Structure

PDB	4P59
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Garner, A.P., Bialucha, C.U., Sprague, E.R., Garrett, J.T., Sheng, Q., Li, S., Sineshchekova, O., Saxena, P., Sutton, C.R., Chen, D., Chen, Y., Wang, H., Liang, J., Das, R., Mosher, R., Gu, J., Huang, A., Haubst, N., Zehetmeier, C., Haberl, M., Elis, W., Kunz, C., Heidt, A.B., Herlihy, K., Murtie, J., Schuller, A., Arteaga, C.L., Sellers, W.R., Ettenberg, S.A. Cancer Res.