CATH Classification

Domain Context

CATH Clusters

Superfamily NadA-like
Functional Family

Enzyme Information

2.5.1.72
Quinolinate synthase.
based on mapping to UniProt Q9X1X7
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.

UniProtKB Entries (1)

Q9X1X7
NADA_THEMA
Thermotoga maritima MSB8
Quinolinate synthase A

PDB Structure

PDB 4P3X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of Fe4S4 quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.
Cherrier, M.V., Chan, A., Darnault, C., Reichmann, D., Amara, P., Ollagnier de Choudens, S., Fontecilla-Camps, J.C.
J.Am.Chem.Soc.