CATH Classification

Domain Context

CATH Clusters

Superfamily Anticodon-binding domain
Functional Family Threonine--tRNA ligase 2, cytoplasmic

Enzyme Information

6.1.1.3
Threonine--tRNA ligase.
based on mapping to UniProt P26639
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

UniProtKB Entries (1)

P26639
SYTC_HUMAN
Homo sapiens
Threonine--tRNA ligase, cytoplasmic

PDB Structure

PDB 4P3N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Fang, P., Yu, X., Jeong, S.J., Mirando, A., Chen, K., Chen, X., Kim, S., Francklyn, C.S., Guo, M.
Nat Commun