CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1
Glycine hydroxymethyltransferase.
based on mapping to UniProt A1SUU0
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

A1SUU0
GLYA_PSYIN
Psychromonas ingrahamii 37
Serine hydroxymethyltransferase

PDB Structure

PDB 4P3M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational transitions driven by pyridoxal-5'-phosphate uptake in the psychrophilic serine hydroxymethyltransferase from Psychromonas ingrahamii.
Angelaccio, S., Dworkowski, F., Di Bello, A., Milano, T., Capitani, G., Pascarella, S.
Proteins