CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt P9WFX5
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

P9WFX5
TRPD_MYCTU
Mycobacterium tuberculosis H37Rv
Anthranilate phosphoribosyltransferase

PDB Structure

PDB 4OWV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Cookson, T.V., Castell, A., Bulloch, E.M., Evans, G.L., Short, F.L., Baker, E.N., Lott, J.S., Parker, E.J.
Biochem.J.