CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.40.1910
Functional Family Aminopeptidase

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P15145
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P15145
AMPN_PIG
Sus scrofa
Aminopeptidase N

PDB Structure

PDB 4OU3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy.
Liu, C., Yang, Y., Chen, L., Lin, Y.L., Li, F.
J.Biol.Chem.