CATH Classification

Domain Context

CATH Clusters

Superfamily Macrophage Migration Inhibitory Factor
Functional Family

Enzyme Information

5.3.2.6
2-hydroxymuconate tautomerase.
based on mapping to UniProt Q01468
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate.
-!- Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. -!- The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex- 3-enedioate by the enzyme. -!- Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme but later shown to be produced non-enzymatically.

UniProtKB Entries (1)

Q01468
4OT1_PSEPU
Pseudomonas putida
2-hydroxymuconate tautomerase

PDB Structure

PDB 4OTA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Native and inhibitor complex structures of 4-oxalocrotonate tautomerase from Pseudomonas putida mt-2 (University of Texas at Austin-136 pages)
Taylor, A.B.
Thesis