CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease III domain
Functional Family Ribonuclease 3

Enzyme Information

3.1.26.3
Ribonuclease III.
based on mapping to UniProt Q02555
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

Q02555
RNT1_YEAST
Saccharomyces cerevisiae S288C
Ribonuclease 3

PDB Structure

PDB 4OOG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection.
Liang, Y.H., Lavoie, M., Comeau, M.A., Abou Elela, S., Ji, X.
Mol.Cell