CATH Classification

Domain Context

CATH Clusters

Superfamily HIV Type 1 Reverse Transcriptase, subunit A, domain 1
Functional Family

Enzyme Information

2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt Q99315
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q99315
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt Q99315
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt Q99315

UniProtKB Entries (1)

Q99315
YG31B_YEAST
Saccharomyces cerevisiae S288C
Transposon Ty3-G Gag-Pol polyprotein

PDB Structure

PDB 4OL8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nowak, E., Miller, J.T., Bona, M.K., Studnicka, J., Szczepanowski, R.H., Jurkowski, J., Le Grice, S.F., Nowotny, M.
Nat.Struct.Mol.Biol.